Scientists from the University of Tottenham, in collaboration with international researchers, have developed a gel capable of repairing and regenerating damaged teeth without the need for surgical procedures.
According to the research team, there is currently no effective method for fully restoring or regenerating teeth — a condition affecting nearly half of the world’s population and costing an estimated $544 billion annually.
Professor Alvaro Mata, Head of the Department of Biomedical Engineering and Bioresources at the University of Tottenham, described the new gel as “safe, simple, and quick to use.” He noted that it can be applied directly to the tooth surface and does not require any surgical intervention, adding that the product is expected to be available commercially next year.
How the Gel Works
The study, published in Nature Communications, explains that the gel mimics the behavior of natural proteins that guide enamel growth during childhood. When applied, it forms a protective mineral layer that fills cracks and cavities, then absorbs calcium, phosphate, and other ions from saliva to promote natural enamel regeneration.
Dr. Abshar Hassan, the study’s lead author, said the gel enables “integrated and orderly crystal growth,” effectively restoring enamel to its natural structure and properties. Laboratory tests simulating chewing and exposure to acidic foods showed that the regenerated enamel performs similarly to healthy enamel.
Professor Mata added that this innovation could pave the way for a range of new dental care products to assist patients of all ages. He noted that commercialization efforts are already underway through the startup Mintek Bio, with the first product expected to launch in 2026.
The Independent reported that the gel could offer a vital solution for millions worldwide suffering from tooth decay and enamel erosion.
