Herpes virus protein from squirrel monkeys boosts immune response against cancer
In a groundbreaking study published in Science Immunology, researchers at the University of Michigan have developed an innovative method to enhance the immune system’s fight against cancer using a protein derived from a herpes virus that infects squirrel monkeys.
The engineered protein, called TIP, significantly strengthens T cells, the immune system’s frontline defenders against cancer and infections. By stimulating STAT5 production, TIP prolongs the survival of these cells, allowing them to maintain their attack on tumors for extended periods.
In laboratory experiments on mice with melanoma and lymphoma, the protein led to a marked slowdown in tumor growth, signaling a major step forward in cancer immunotherapy — a field that aims to harness and boost the body’s natural defenses.
Researchers believe TIP could eventually be used in combination with existing immunotherapies to increase their effectiveness and may pave the way for genetic modifications in other organisms to further support immune function.
While the results are highly promising, scientists stress that further studies are required to verify the safety and effectiveness in humans before it can be developed into a viable treatment.
The study adds to growing global interest in virus-based cancer therapies, including current clinical trials involving modified herpes simplex viruses designed to directly target tumors — a strategy already showing encouraging early results.
