A plane and its passengers are set to test the mental and physical limits of long-haul aviation when Qantas operates the first direct flight by a commercial airline from New York to Sydney this weekend.

In the first of three “ultra long-haul” test flights planned by Australia’s national flag carrier this year, researchers will monitor the effects on passengers of the 19-hour non-stop journey.

Up to 40 passengers and crew – most of them Qantas employees – will be on board the Boeing 787-9 when it departs New York on Friday. The plane is scheduled to arrive Down Under Sunday morning.