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Type 2 diabetes drug targets glucose production in liver
September 29, 2015, 3:10 pm

Researchers believe that rather than attempting to make the body more sensitive to insulin, it is possible to treat type 2 diabetes by slowing the production of glucose in the liver.

A team in the US has found that shutting down a liver protein that controls glucose production, through the use of a drug, led to lower levels of blood sugar in mice. The finding could lead to more effective treatments for type 2 diabetes.

Researchers found that by inhibiting a protein in the liver of mice they were able to block the transport of a specific building block of glucose, called pyruvate, from the bloodstream into the liver and thereby cut glucose production.

The team believes that disrupting the transport of pyruvate may also help treat nonalcoholic fatty liver disease - a condition that is common in people who are obese and which could in some cases lead to inflammation and scarring of the liver and in rare cases cause liver failure.

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